Scientists have developed a new way to administer drugs through the skin
Researchers have shown that when the skin is compressed, micropores are formed in the folds of the skin, through which the same amount of medicine can penetrate as through dozens of microneedles.
Scientists at Nanyang Technological University were inspired by a traditional Chinese medicine method called tuina massage, during which doctors rub in an ointment, applying pressure to the patient’s skin and muscle tissue. In the course of research, it was found that skin compression leads to a short-term change in its structure with the formation of pores with a diameter of 3 microns.
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Tests have shown that six times more drugs can penetrate through these micropores than with conventional transdermal administration. In addition to the fact that this process is painless, it allows you to inject particles with a molecular weight of up to 20 thousand daltons, which is 40 times more than the usual indicator, and also to control the rate of drug intake. Micropores completely disappear one day after their formation.
Experiments have shown that the effectiveness of insulin injection using this method is similar to a medical patch with dozens of microneedles, and the ability to control the speed minimizes the risk of hypoglycemia.
Scientists plan to improve this method and one day save people who have to inject every day from using needles and piercing their skin.
Earlier we also reported on the development of a convenient blood pressure monitor in the form of a patch.
, Nanyang Technological University