Scientists learned how to edit genes using red light
Researchers have developed a new system that allows you to edit genes in mammalian cells based on far red light.
Far red is between red and infrared (710-800 nm), although it is visible, but because of the low photon energy it does not participate in photosynthesis. Recently, a team from the Institute of Biomedical Sciences of China found that using it can make it easier to change the structure of the genome in organs.
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Using the split-Cas9 system in combination with lighting based on high-red LEDs, scientists were able to efficiently edit individual sections of genes located in mammalian cells, including non-homologous junction of ends and homologically directed restoration. Using the new method, the team successfully changed the oncogen in the mouse tumor.
The study also showed that the new system can be used for programmed editing of the tissue genome in a biological and biomedical context with high accuracy.
Recall that in March we developed a technology that allows you to delete pathological memories using CRISPR.